Inhibition of S6K by resveratrol

Long-term every-other-day administration of DMAMCL has little effect on aging Abstract The activation of transcription factor NF-κB is currently identified as one of the driving forces to the aging process. Genetic impairment of NF-κB signaling pathway or pharmacological inhibition of NF-κB activity has been shown to extend healthspan and lifespan in animal models, and delay or reduce many age-related symptoms. However, the aging intervention strategies based on NF-κB inhibition by the suitable small molecular compound is currently still lacking. The water-soluble dimethylaminomicheliolide (DMAMCL), can inhibit NF-κB activity and is currently undergoing clinical trials. In this study, we showed that 15 months of DMAMCL administration started in 1-year old male mice was well-tolerated and safe, and improved or had little effect on some age-associated symptoms, such as neurobehavioral phenotypes, physical performance, cardiac function, hematological parameters, immune aging phenotypes, c...

Inhibition of S6K by resveratrol: In search of the purpose Mikhail V. Blagosklonny 1 1  Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA Received: May 28, 2009          Accepted: June 27, 2009          Published: June 29, 2009 https://doi.org/10.18632/aging.100059 How to Cite Mechanisms of the anti-aging effects of resveratrol Resveratrol, a natural agent found in grape skins, has been proposed to account for the beneficial effects of red wine against heart disease. Resveratrol prevents age-related diseases and extends lifespan in several species [ 1 - 9 ]. In this issue of Aging, Armour  et al  demonstrate that resveratrol directly inhibits S6 kinase (S6K) [ 10 ]. S6K is a downstream target of mTOR (mammalian Target of Rapamycin). In response to nutrients, growth factors and hormones, the mTOR/S6K pathway promotes cellular mass growth, which is needed for cell proliferation. In post-mitotic (...